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mAbs

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4.634

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An open access journal publishing antibody research on topics including targets relevant to cancer and immune-mediated disorders, and antibody therapeutics.
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Volume 12, 2020 Vol 11, 2019 Vol 10, 2018 Vol 9, 2017 Vol 8, 2016 Vol 7, 2015 Vol 6, 2014 Vol 5, 2013 Vol 4, 2012 Vol 3, 2011 Vol 2, 2010 Vol 1, 2009
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mAbs, Volume 12, Issue 1 (2020)

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Pharmacokinetics of novel Fc-engineered monoclonal and multispecific antibodies in cynomolgus monkeys and humanized FcRn transgenic mouse models
Delphine Valente , Christine Mauriac , Thorsten Schmidt , Ingo Focken , Jochen Beninga , Brian Mackness , Huawei Qiu , Pascale Vicat , Abdullah Kandira , Katarina Rado拧evi膰 , Srini Rao , John Darbyshire & Mostafa Kabiri
旺财体育: 1829337
Published online: 20 Oct 2020
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Cross-species/cross-modality physiologically based pharmacokinetics for biologics: 89Zr-labelled albumin-binding domain antibody GSK3128349 in humans
Armin Sepp , Mats Bergstr枚m & Marie Davies
旺财体育: 1832861
Published online: 19 Oct 2020
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  • 74Views
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Short Communication

Design of next-generation therapeutic IgG4 with improved manufacturability and bioanalytical characteristics
Zhiqiang Chen , Yueming Qian , Yuanli Song , Xuankuo Xu , Li Tao , Nesredin Mussa , Sanchayita Ghose & Zheng Jian Li
旺财体育: 1829338
Published online: 12 Oct 2020
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  • 294Views
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Optimization and kinetic modeling of interchain disulfide bond reoxidation of monoclonal antibodies in bioprocesses
Peifeng Tang , Zhijun Tan , Vivekh Ehamparanathan , Tingwei Ren , Laurel Hoffman , Cheng Du , Yuanli Song , Li Tao , Angela Lewandowski , Sanchayita Ghose , Zheng Jian Li & Shijie Liu
旺财体育: 1829336
Published online: 08 Oct 2020
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  • 279Views
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Functional humanization of immunoglobulin heavy constant gamma 1 Fc domain human FCGRT transgenic mice
Benjamin E. Low , Gregory J. Christianson , Emily Lowell , Wenning Qin & Michael V. Wiles
旺财体育: 1829334
Published online: 07 Oct 2020
Abstract | Full Text | References | PDF (2362 KB) | Supplemental | Permissions聽

  • 288Views
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On-column disulfide bond formation of monoclonal antibodies during Protein A chromatography eliminates low molecular weight species and rescues reduced antibodies
Zhijun Tan , Vivekh Ehamparanathan , Tingwei Ren , Peifeng Tang , Laurel Hoffman , June Kuang , Peiran Liu , Chao Huang , Cheng Du , Li Tao , Letha Chemmalil , Angela Lewandowski , Sanchayita Ghose , Zheng Jian Li & Shijie Liu
旺财体育: 1829333
Published online: 04 Oct 2020
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  • 460Views
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A minimal physiologically based pharmacokinetic model to characterize colon TNF suppression and treatment effects of an anti-TNF monoclonal antibody in a mouse inflammatory bowel disease model
Songmao Zheng , Jin Niu , Brian Geist , Damien Fink , Zhenhua Xu , Honghui Zhou & Weirong Wang
旺财体育: 1813962
Published online: 24 Sep 2020
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An accelerated surface-mediated stress assay of antibody instability for developability studies
Marie R.G. Kopp , Adriana-Michelle Wolf P茅rez , Marta Virginia Zucca , Umberto Capasso Palmiero , Brigitte Friedrichsen , Nikolai Lorenzen & Paolo Arosio
旺财体育: 1815995
Published online: 20 Sep 2020
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  • 881Views
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Molecular computations of preferential interactions of proline, arginine.HCl, and NaCl with IgG1 antibodies and their impact on aggregation and viscosity
Theresa K. Cloutier , Chaitanya Sudrik , Neil Mody , Sathish A. Hasige & Bernhardt L. Trout
旺财体育: 1816312
Published online: 17 Sep 2020
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  • 444Views
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Targeted IgMs agonize ocular targets with extended vitreal exposure
Yvonne Chen , Maciej Paluch , Julie A. Zorn , Sharmila Rajan , Brandon Leonard , Alberto Estevez , John Brady , Henry Chiu , Wilson Phung , Amin Famili , Minhong Yan , Claudio Ciferri , Marissa L. Matsumoto , Greg A. Lazar , Susan Crowell , Phil Hass & Nicholas J. Agard
旺财体育: 1818436
Published online: 16 Sep 2020
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  • 395Views
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Engineered Fc-glycosylation switch to eliminate antibody effector function
Qun Zhou , Julie Jaworski , Yanfeng Zhou , Delphine Valente , Joanne Cotton , Denise Honey , Ekaterina Boudanova , Jochen Beninga , Ercole Rao , Ronnie Wei , Christine Mauriac , Clark Pan , Anna Park & Huawei Qiu
旺财体育: 1814583
Published online: 06 Sep 2020
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Measuring aggregates, self-association, and weak interactions in concentrated therapeutic antibody solutions
Sumit K. Chaturvedi , Arun Parupudi , Kristian Juul-Madsen , Ai Nguyen , Thomas Vorup-Jensen , Sonia Dragulin-Otto , Huaying Zhao , Reza Esfandiary & Peter Schuck
旺财体育: 1810488
Published online: 04 Sep 2020
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  • 1042Views
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Biophysical and biochemical characterization of a VHH-based IgG-like bi- and trispecific antibody platform
Lukas Pekar , Michael Busch , Bernhard Valldorf , Steffen C. Hinz , Lars Toleikis , Simon Krah & Stefan Zielonka
旺财体育: 1812210
Published online: 04 Sep 2020
Abstract | Full Text | References | PDF (3135 KB) | Supplemental | Permissions聽

  • 1858Views
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Biased anti-idiotype response in rabbits leads to high-affinity monoclonal antibodies to biologics
Christina Gro脽erichter-Wagener , Dorien Kos , Astrid van Leeuwen , Lisanne Dijk , Jorn Jeremiasse , Floris C. Loeff & Theo Rispens
旺财体育: 1814661
Published online: 04 Sep 2020
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  • 339Views
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Structural and functional characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 function via a novel non-competitive mechanism of action
Mark Austin , Daniel Burschowsky , Denice T.Y. Chan , Lesley Jenkinson , Stuart Haynes , Agata Diamandakis , Chitra Seewooruthun , Alexandra Addyman , Sebastian Fiedler , Stephanie Ryman , Jessica Whitehouse , Louise H. Slater , Andreas V. Hadjinicolaou , Uzi Gileadi , Ellen Gowans , Yoko Shibata , Michelle Barnard , Teresa Kaserer , Pooja Sharma , Nadia M. Luheshi , Robert W. Wilkinson , Tristan J. Vaughan , Sarah V. Holt , Vincenzo Cerundolo , Mark D. Carr & Maria A. T. Groves
旺财体育: 1801230
Published online: 03 Sep 2020
Abstract | Full Text | References | PDF (9319 KB) | Supplemental | Permissions聽

  • 936Views
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CD40- and CD95-specific antibody single chain-Baff fusion proteins display BaffR-, TACI- and BCMA-restricted agonism
Johannes Nelke , Juliane Medler , Daniela Weisenberger , Andreas Beilhack & Harald Wajant
旺财体育: 1807721
Published online: 25 Aug 2020
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  • 406Views
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Novel monoclonal antibodies to the SERINC5 HIV-1 restriction factor detect endogenous and virion-associated SERINC5
Sebastian Molnar , Lindsay Wieczorek , Michelle Zemil , Bianca Schulte , Elizabeth Martinez , Syna Gift , Lan Tang , Hendrik Streeck , Robert A. Gramzinski , Nelson L. Michael , Gordon Joyce & Victoria R. Polonis
旺财体育: 1802187
Published online: 23 Aug 2020
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  • 555Views
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AlbuCORE: an albumin-based molecular scaffold for multivalent biologics design
Mario Sanches , Igor D鈥橝ngelo , Maria Jaramillo , Jason Baardsnes , John Zwaagstra , Joe Schrag , Ian Schoenhofen , Mauro Acchione , Sam Lawn , Grant Wickman , Nina Weisser , David K. Y. Poon , Gordon Ng & Surjit Dixit
旺财体育: 1802188
Published online: 20 Aug 2020
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Assessment of the role of afucosylated glycoforms on the in vitro antibody-dependent phagocytosis activity of an antibody to A尾 aggregates
Allyson Kwiatkowski , Carl Co , Sei Kameoka , An Zhang , John Coughlin , Tom Cameron , Eric Chiao , Svetlana Bergelson & Cullen Schmid Mason
旺财体育: 1803645
Published online: 19 Aug 2020
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  • 483Views
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Brief report

brief report
A novel biparatopic hybrid antibody-ACE2 fusion that blocks SARS-CoV-2 infection: implications for therapy
Xiaoniu Miao , Yi Luo , Xi Huang , Suki M. Y. Lee , Zhijun Yuan , Yongzhou Tang , Liandi Chen , Chao Wang , Fan Wu , Yifeng Xu , Wenchao Jiang , Wei Gao , Xuedong Song , Yao Yan , Tuling Pang , Cheng Chen , Yuefeng Zou , Weihui Fu , Liping Wan , Javier Gilbert-Jaramillo , Michael Knight , Tiong Kit Tan , Pramila Rijal , Alain Townsend , Joanne Sun , Xiaolin Liu , William James , Andy Tsun & Yingda Xu
旺财体育: 1804241
Published online: 17 Aug 2020
Abstract | Full Text | References | PDF (2670 KB) | Supplemental | Permissions聽

  • 987Views
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Report

Antigen physiochemical properties allosterically effect the IgG Fc-region and Fc neonatal receptor affinity
Yue Sun , Alberto Estevez , Tilman Schlothauer & Aaron T. Wecksler
旺财体育: 1802135
Published online: 14 Aug 2020
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  • 803Views
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Affinity maturation of antibodies by combinatorial codon mutagenesis versus error-prone PCR
Jan Fredrik Simons , Yoong Wearn Lim , Kyle P. Carter , Ellen K. Wagner , Nicholas Wayham , Adam S. Adler & David S. Johnson
旺财体育: 1803646
Published online: 11 Aug 2020
Abstract | Full Text | References | PDF (9063 KB) | Supplemental | Permissions聽

  • 1496Views
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Malignant tissues produce divergent antibody glycosylation of relevance for cancer gene therapy effectiveness
Dominik Br眉cher , Vojtech Franc , Sheena N. Smith , Albert J. R. Heck & Andreas Pl眉ckthun
旺财体育: 1792084
Published online: 04 Aug 2020
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  • 979Views
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Perspective

The Antibody Society鈥檚 antibody validation webinar series
Jan L.A. Voskuil , Anita Bandrowski , C. Glenn Begley , Andrew R.M. Bradbury , Andrew D. Chalmers , Aldrin V. Gomes , Travis Hardcastle , Fridtjof Lund-Johansen , Andreas Pl眉ckthun , Giovanna Roncador , Alejandra Solache , Michael J. Taussig , James S. Trimmer , Cecilia Williams & Simon L. Goodman
旺财体育: 1794421
Published online: 04 Aug 2020
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  • 1783Views
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Report

A general evidence-based sequence variant control limit for recombinant therapeutic protein development
Aming Zhang , Zhengwei Chen , Meinuo Li , Haibo Qiu , Shawn Lawrence , Hanne Bak & Ning Li
旺财体育: 1791399
Published online: 02 Aug 2020
Abstract | Full Text | References | PDF (2633 KB) | Supplemental | Permissions聽

  • 1018Views
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Bivalent binding on cells varies between anti-CD20 antibodies and is dose-dependent
Sina Bondza , Toine ten Broeke , Marika Nestor , Jeanette H. W. Leusen & Jos Buijs
旺财体育: 1792673
Published online: 02 Aug 2020
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  • 698Views
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Conjugation of a peptide to an antibody engineered with free cysteines dramatically improves half-life and activity
Raul C. Camacho , Seohee You , Katharine E. D鈥橝quino , Wenyu Li , Yuanping Wang , Joseph Gunnet , James Littrell , Jian Shen Qi , Lijuan Kang , Wenying Jian , Mary MacDonald , Timothy Tat , Derek Steiner , Yue-Mei Zhang , James Lanter , Raymond Patch , Rui Zhang , Jiali Li , Suzanne Edavettal , Wilson Edwards , Thai Dinh , Li Ying Wang , Judy Connor , Michael Hunter , Ellen Chi , Ronald V. Swanson , James N. Leonard & Martin A. Case
旺财体育: 1794687
Published online: 02 Aug 2020
Abstract | Full Text | References | PDF (1473 KB) | Supplemental | Permissions聽

  • 784Views
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Development and validation of an LC-MS/MS method for simultaneous quantification of co-administered trastuzumab and pertuzumab
Sandor Schokker , Fabrizia Fusetti , Francesco Bonardi , Remco J. Molenaar , Ron A.A. Math么t & Hanneke W.M. van Laarhoven
旺财体育: 1795492
Published online: 02 Aug 2020
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  • 537Views
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Novel chimerized IgA CD20 antibodies: Improving neutrophil activation against CD20-positive malignancies
Mitchell Evers , Toine Ten Broeke , J.H. Marco Jansen , Maaike Nederend , Firas Hamdan , Karli R. Reiding , Saskia Meyer , Petra Moerer , Iris Brinkman , Thies R枚sner , Robert Jan Lebbink , Thomas Valerius & Jeanette H.W. Leusen
旺财体育: 1795505
Published online: 02 Aug 2020
Abstract | Full Text | References | PDF (1987 KB) | Supplemental | Permissions聽

  • 435Views
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COBRA鈩�: a highly potent conditionally active T cell engager engineered for the treatment of solid tumors
Anand Panchal , Pui Seto , Russell Wall , Brian J. Hillier , Ying Zhu , Jessica Krakow , Aakash Datt , Elizabeth Pongo , Andisheh Bagheri , Tseng-Hui T. Chen , Jeremiah D. Degenhardt , Patricia A. Culp , Danielle E. Dettling , Maia V. Vinogradova , Chad May & Robert B. DuBridge
旺财体育: 1792130
Published online: 19 Jul 2020
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  • 1941Views
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Rational optimization of a monoclonal antibody improves the aggregation propensity and enhances the CMC properties along the entire pharmaceutical process chain
Joschka Bauer , Sven Mathias , Sebastian Kube , Kerstin Otte , Patrick Garidel , Martin Gamer , Michaela Blech , Simon Fischer & Anne R Karow-Zwick
旺财体育: 1787121
Published online: 13 Jul 2020
Abstract | Full Text | References | PDF (6790 KB) | Supplemental | Permissions聽

  • 2114Views
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A Phase 1 and pharmacokinetic study evaluating daily or weekly schedules of the humanized anti-GD2 antibody hu14.18K322A in recurrent/refractory solid tumors
Michael W. Bishop , Paul R. Hutson , Jacquelyn A. Hank , Paul M. Sondel , Wayne L. Furman , Michael M. Meagher , Fariba Navid & Victor M. Santana
旺财体育: 1773751
Published online: 09 Jul 2020
Abstract | Full Text | References | PDF (1830 KB) | Supplemental | Permissions聽

  • 447Views
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An evaluation of instrument types for mass spectrometry-based multi-attribute analysis of biotherapeutics
Zhongqi Zhang , Pik K. Chan , Jason Richardson & Bhavana Shah
旺财体育: 1783062
Published online: 09 Jul 2020
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  • 705Views
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Prevention of Fab-arm exchange and antibody reduction via stabilization of the IgG4 hinge region
Michael W. Handlogten , Li Peng , Elizabeth A. Christian , Weichen Xu , Shihua Lin , Raghavan Venkat , William Dall鈥橝cqua & Sanjeev Ahuja
旺财体育: 1779974
Published online: 07 Jul 2020
Abstract | Full Text | References | PDF (6946 KB) | Supplemental | Permissions聽

  • 984Views
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Investigation of monoclonal antibody dimers in a final formulated drug by separation techniques coupled to native mass spectrometry
G. Rouby , N. T. Tran , Y. Leblanc , M. Taverna & N. Bihoreau
旺财体育: e1781743
Published online: 07 Jul 2020
Abstract | Full Text | References | PDF (1172 KB) | Supplemental | Permissions聽

  • 708Views
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Perspective

Ig-like ACE2 protein therapeutics: A revival in development during the COVID-19 pandemic
Kewen Qian & Shi Hu
旺财体育: e1782600
Published online: 07 Jul 2020
Abstract | Full Text | References | PDF (599 KB) | Permissions聽

  • 1928Views
  • 2CrossRef citations
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Report

Characterization of concurrent target suppression by JNJ-61178104, a bispecific antibody against human tumor necrosis factor and interleukin-17A
Songmao Zheng , Fang Shen , Brian Jones , Damien Fink , Brian Geist , Ivo Nnane , Zhao Zhou , Jeff Hall , Ravi Malaviya , Tatiana Ort & Weirong Wang
旺财体育: 1770018
Published online: 16 Jun 2020
Abstract | Full Text | References | PDF (2603 KB) | Supplemental | Permissions聽

  • 1066Views
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Short communication

Potent neutralization of SARS-CoV-2 by human antibody heavy-chain variable domains isolated from a large library with a new stable scaffold
Zehua Sun , Chuan Chen , Wei Li , David R. Martinez , Aleksandra Drelich , Du-San Baek , Xianglei Liu , John W. Mellors , Chien-Te Tseng , Ralph S. Baric & Dimiter S. Dimitrov
旺财体育: 1778435
Published online: 16 Jun 2020
Abstract | Full Text | References | PDF (1347 KB) | Supplemental | Permissions聽

  • 1811Views
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Report

Biomanufacturing evolution from conventional to intensified processes for productivity improvement: a case study
Jianlin Xu , Xuankuo Xu , Chao Huang , James Angelo , Christopher L. Oliveira , Mengmeng Xu , Xia Xu , Deniz Temel , Julia Ding , Sanchayita Ghose , Michael C. Borys & Zheng Jian Li
旺财体育: 1770669
Published online: 08 Jun 2020
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  • 2625Views
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Influence of physiochemical properties on the subcutaneous absorption and bioavailability of monoclonal antibodies
Amita Datta-Mannan , Selina Estwick , Chen Zhou , Hiuwan Choi , Nicole E. Douglass , Derrick R. Witcher , Jirong Lu , Catherine Beidler & Rohn Millican
旺财体育: 1770028
Published online: 03 Jun 2020
Abstract | Full Text | References | PDF (1083 KB) | Supplemental | Permissions聽

  • 1406Views
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Enabling speed to clinic for monoclonal antibody programs using a pool of clones for IND-enabling toxicity studies
Parimala Bolisetty , Gabi Tremml , Sen Xu & Anurag Khetan
旺财体育: 1763727
Published online: 25 May 2020
Abstract | Full Text | References | PDF (1523 KB) | Permissions聽

  • 1560Views
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Benchmarking biopharmaceutical process development and manufacturing cost contributions to R&D
Suzanne S. Farid , Max Baron , Christos Stamatis , Wenhao Nie & Jon Coffman
旺财体育: 1754999
Published online: 23 May 2020
Abstract | Full Text | References | PDF (2687 KB) | Supplemental | Permissions聽

  • 3195Views
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report
Investigation of anomalous charge variant profile reveals discrete pH-dependent conformations and conformation-dependent charge states within the CDR3 loop of a therapeutic mAb
Wenkui Lan, Joseph J. Valente, Andrew Ilott, Naresh Chennamsetty, Zhihua Liu, Joseph M. Rizzo, Aaron P. Yamniuk, Difei Qiu, Holly M. Shackman & Mark S. Bolgar
旺财体育: 1763138
Published online: 20 May 2020
Abstract | Full Text | References | PDF (2504 KB) | Supplemental | Permissions聽

  • 1275Views
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Hyphenation of strong cation exchange chromatography to native mass spectrometry for high throughput online characterization of charge heterogeneity of therapeutic monoclonal antibodies
Fengfei Ma, Fahimeh Raoufi, Marc Andre Bailly, Laurence Fayadat-Dilman & Daniela Tomazela
旺财体育: 1763762
Published online: 20 May 2020
Abstract | Full Text | References | PDF (3715 KB) | Supplemental | Permissions聽

  • 1666Views
  • 1CrossRef citations
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Post-hoc assessment of the immunogenicity of three antibodies reveals distinct immune stimulatory mechanisms
Robin E. Walsh, Megan Lannan, Yi Wen, Xiaoli Wang, Christopher A. Moreland, Jill Willency, Michael D. Knierman, Laura Spindler, Ling Liu, Wei Zeng, Guilherme V. Rocha, Victor Obungu, Jirong Lu, Arunan Kaliyaperumal, Andrea Ferrante, Robert Siegel & Laurent P. Malherbe
旺财体育: 1764829
Published online: 18 May 2020
Abstract | Full Text | References | PDF (2539 KB) | Permissions聽

  • 1905Views
  • 1CrossRef citations
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Human-likeness of antibody biologics determined by back-translation and comparison with large antibody variable gene repertoires
Samuel Schmitz, Cinque Soto, James E. Crowe Jr. & Jens Meiler
旺财体育: 1758291
Published online: 13 May 2020
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  • 1253Views
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Rapid identification of highly potent human anti-GPCR antagonist monoclonal antibodies
Martin J. Scott, Amanda Jowett, Martin Orecchia, Peter Ertl, Larissa Ouro-Gnao, Julia Ticehurst, David Gower, John Yates, Katie Poulton, Carol Harris, Michael J. Mullin, Kathrine J. Smith, Alan P. Lewis, Nick Barton, Michael L. Washburn & Ruud de Wildt
旺财体育: 1755069
Published online: 28 Apr 2020
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  • 2566Views
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In vitro affinity optimization of an anti-BDNF monoclonal antibody translates to improved potency in targeting chronic pain states in vivo
Edwina Stack, Sheridan McMurray, Gordon McMurray, Jason Wade, Melissa Clark, Gareth Young, Kim Marquette, Sadhana Jain, Kerry Kelleher, Ting Chen, Qingcong Lin, Laird Bloom, Laura Lin, William Finlay, Rie Suzuki & Orla Cunningham
旺财体育: 1755000
Published online: 24 Apr 2020
Abstract | Full Text | References | PDF (3592 KB) | Supplemental | Permissions聽

  • 1386Views
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Multimeric antibodies with increased valency surpassing functional affinity and potency thresholds using novel formats
Ami Miller , Stephen Carr , Terry Rabbitts & Hanif Ali
旺财体育: 1752529
Published online: 22 Apr 2020
Abstract | Full Text | References | PDF (3636 KB) | Supplemental | Permissions聽

  • 1396Views
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旺财体育
Preclinical characterization of the ADME properties of a surrogate anti-IL-36R monoclonal antibody antagonist in mouse serum and tissues
Kip P. Conner, Cinthia V. Pastuskovas, Marcus Soto, Veena A. Thomas, Mylo Wagner & Dan A. Rock
旺财体育: 1746520
Published online: 20 Apr 2020
Abstract | Full Text | References | PDF (4139 KB) | Supplemental | Permissions聽

  • 1136Views
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An overview of patents on therapeutic monoclonal antibodies in Europe: are they a hurdle to biosimilar market entry?
Evelien Moorkens, Arnold G. Vulto & Isabelle Huys
旺财体育: 1743517
Published online: 19 Apr 2020
Abstract | Full Text | References | PDF (1445 KB) | Permissions聽

  • 1832Views
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A rapid method for relative quantification of N-glycans from a therapeutic monoclonal antibody during trastuzumab biosimilar development
Zaneer Segu, Todd Stone, Claudia Berdugo, Anthony Roberts, Emma Doud & Yunsong Li
旺财体育: 1750794
Published online: 19 Apr 2020
Abstract | Full Text | References | PDF (3655 KB) | Supplemental | Permissions聽

  • 1776Views
  • 1CrossRef citations
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Characterization of therapeutic proteins by cation exchange chromatography-mass spectrometry and top-down analysis
Rachel Liuqing Shi, Gang Xiao, Thomas M. Dillon, Margaret S. Ricci & Pavel V. Bondarenko
旺财体育: 1739825
Published online: 15 Apr 2020
Abstract | Full Text | References | PDF (2946 KB) | Supplemental | Permissions聽

  • 1539Views
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Dose escalation PET imaging for safety and effective therapy dose optimization of a bispecific antibody
Yan Wang, Donghui Pan, Chenrong Huang, Bingliang Chen, Mingzhu Li, Shuaixiang Zhou, Lizhen Wang, Min Wu, Xinyu Wang, Yicong Bian, Junjie Yan, Junjian Liu, Min Yang & Liyan Miao
旺财体育: 1748322
Published online: 10 Apr 2020
Abstract | Full Text | References | PDF (3324 KB) | Supplemental | Permissions聽

  • 848Views
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Antibody CDR loops as ensembles in solution vs. canonical clusters from X-ray structures
Monica L. Fern谩ndez-Quintero, Martin C. Heiss, Nancy D. Pomarici, Barbara A. Math & Klaus R. Liedl
旺财体育: 1744328
Published online: 07 Apr 2020
Abstract | Full Text | References | PDF (3266 KB) | Supplemental | Permissions聽

  • 1014Views
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Predicting Antibody Developability Profiles Through Early Stage Discovery Screening
Marc Bailly, Carl Mieczkowski, Veronica Juan, Essam Metwally, Daniela Tomazela, Jeanne Baker, Makiko Uchida, Ester Kofman, Fahimeh Raoufi, Soha Motlagh, Yao Yu, Jihea Park, Smita Raghava, John Welsh, Michael Rauscher, Gopalan Raghunathan, Mark Hsieh, Yi-Ling Chen, Hang Thu Nguyen, Nhung Nguyen, Dan Cipriano & Laurence Fayadat-Dilman
旺财体育: 1743053
Published online: 05 Apr 2020
Abstract | Full Text | References | PDF (7370 KB) | Supplemental | Permissions聽

  • 4910Views
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Potent neutralizing monoclonal antibodies against Ebola virus isolated from vaccinated donors
Pengfei Fan, Xiangyang Chi, Guodong Liu, Guanying Zhang, Zhengshan Chen, Yujiao Liu, Ting Fang, Jianmin Li, Logan Banadyga, Shihua He, Changming Yu, Xiangguo Qiu & Wei Chen
旺财体育: 1742457
Published online: 26 Mar 2020
Abstract | Full Text | References | PDF (5933 KB) | Supplemental | Permissions聽

  • 1234Views
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Analytical characterization of coformulated antibodies as combination therapy
Jun Kim, Yoen Joo Kim, Mingyan Cao, Niluka De Mel, Kenneth Miller, Jared S. Bee, Jihong Wang, Xiangyang Wang & Methal Albarghouthi
旺财体育: 1738691
Published online: 21 Mar 2020
Abstract | Full Text | References | PDF (3628 KB) | Supplemental | Permissions聽

  • 1701Views
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Targeting a membrane-proximal epitope on mesothelin increases the tumoricidal activity of a bispecific antibody blocking CD47 on mesothelin-positive tumors
Eric Hatterer, Xavier Chauchet, Fran莽oise Richard, Leticia Barba, Val茅ry Moine, Laurence Chatel, Lucile Broyer, Guillemette Pontini, Tereza Bautzova, Flora Juan, Sebastien Calloud, Nicolas Bosson, Maud Charreton, Krzysztof Masternak, Vanessa Buatois & Limin Shang
旺财体育: 1739408
Published online: 19 Mar 2020
Abstract | Full Text | References | PDF (1591 KB) | Supplemental | Permissions聽

  • 1587Views
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Interaction analysis of glycoengineered antibodies with CD16a: a native mass spectrometry approach
Joanna Hajduk, Cyrill Brunner, Sebastian Malik, Jana Bangerter, Gisbert Schneider, Marco Thomann, Dietmar Reusch & Renato Zenobi
旺财体育: 1736975
Published online: 13 Mar 2020
Abstract | Full Text | References | PDF (2417 KB) | Supplemental | Permissions聽

  • 1214Views
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Intein mediated high throughput screening for bispecific antibodies
Tim Hofmann, Johannes Schmidt, Elke Ciesielski, Stefan Becker, Thomas Rysiok, Mark Sch眉tte, Lars Toleikis, Harald Kolmar & Achim Doerner
旺财体育: 1731938
Published online: 09 Mar 2020
Abstract | Full Text | References | PDF (5192 KB) | Supplemental | Permissions聽

  • 2019Views
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HX008: a humanized PD-1 blocking antibody with potent antitumor activity and superior pharmacologic properties
Jibin Zhang, Ying Huang, Gan Xi & Faming Zhang
旺财体育: 1724751
Published online: 27 Feb 2020
Abstract | Full Text | References | PDF (2644 KB) | Supplemental | Permissions聽

  • 1555Views
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Review

review
Understanding the human antibody repertoire
Anthony R Rees
旺财体育: 1729683
Published online: 25 Feb 2020
Abstract | Full Text | References | PDF (1994 KB) | Permissions聽

  • 3116Views
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Meeting Report

report
10th European immunogenicity platform open symposium on immunogenicity of biopharmaceuticals
S. Tourdot, A. Abdolzade-Bavil, J. Bessa, P. Bro毛t, A. Fogdell-Hahn, M. Giorgi, V. Jawa, K. Kuranda, N. Legrand, S. Pattijn, J. A. Pedras-Vasconcelos, A. Rudy, P. Salmikangas, D. W. Scott, V. Snoeck, N. Smith, S. Spindeldreher & D. Kramer
旺财体育: 1725369
Published online: 16 Feb 2020
Abstract | Full Text | References | PDF (872 KB) | Permissions聽

  • 1224Views
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Review

review article
Anti-ErbB2 immunotherapeutics: struggling to make better antibodies for cancer therapy
Rita De Santis
旺财体育: 1725346
Published online: 13 Feb 2020
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  • 1738Views
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Report

report
A functional antibody cross-reactive to both human and murine cytotoxic T-lymphocyte-associated protein 4 via binding to an N-glycosylation epitope
Dong Li, Jing Li, Huanyu Chu & Zhuozhi Wang
旺财体育: 1725365
Published online: 13 Feb 2020
Abstract | Full Text | References | PDF (3963 KB) | Supplemental | Permissions聽

  • 924Views
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Restricted epitope specificity determined by variable region germline segment pairing in rodent antibody repertoires
Yi-Chun Hsiao, Ying-Jiun J. Chen, Leonard D. Goldstein, Jia Wu, Zhonghua Lin, Kellen Schneider, Subhra Chaudhuri, Aju Antony, Kanika Bajaj Pahuja, Zora Modrusan, Dhaya Seshasayee, Somasekar Seshagiri & Isidro H枚tzel
旺财体育: 1722541
Published online: 10 Feb 2020
Abstract | Full Text | References | PDF (5749 KB) | Supplemental | Permissions聽

  • 1081Views
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Exploiting next-generation sequencing in antibody selections 鈥� a simple PCR method to recover binders
Fortunato Ferrara, Andre A. Teixeira, Leslie Naranjo, M. Frank Erasmus, Sara D鈥橝ngelo & Andrew R.M. Bradbury
旺财体育: 1701792
Published online: 05 Feb 2020
Abstract | Full Text | References | PDF (4722 KB) | Permissions聽

  • 2872Views
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A novel human monoclonal antibody specific to the A33 glycoprotein recognizes colorectal cancer and inhibits metastasis
Patrizia Murer, Louis Pl眉ss & Dario Neri
旺财体育: 1714371
Published online: 03 Feb 2020
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  • 1359Views
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Improved translation of stability for conjugated antibodies using an in vitro whole blood assay
Aimee Fourie-O鈥橠onohue, Phillip Y. Chu, Josefa dela Cruz Chuh, Robert Tchelepi, Siao Ping Tsai, John C. Tran, William S. Sawyer, Dian Su, Carl Ng, Keyang Xu, Shang-Fan Yu, Thomas H. Pillow, Jack Sadowsky, Peter S. Dragovich, Yichin Liu & Katherine R. Kozak
旺财体育: 1715705
Published online: 30 Jan 2020
Abstract | Full Text | References | PDF (4319 KB) | Supplemental | Permissions聽

  • 1253Views
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Investigation of the effect of salt additives in Protein L affinity chromatography for the purification of tandem single-chain variable fragment bispecific antibodies
Serene W. Chen, Darryl Tan, Yuan Sheng Yang & Wei Zhang
旺财体育: 1718440
Published online: 25 Jan 2020
Abstract | Full Text | References | PDF (3300 KB) | Supplemental | Permissions聽

  • 1939Views
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In situ antibody phage display yields optimal inhibitors of integrin 伪11/尾1
Eugenio Gallo, Abdellali Kelil, Peter E. Bayliss, Ajitha Jeganathan, Olga Egorova, Lynda Ploder, Jarrett J. Adams, Patricia Giblin & Sachdev S. Sidhu
旺财体育: 1717265
Published online: 24 Jan 2020
Abstract | Full Text | References | PDF (7104 KB) | Supplemental | Permissions聽

  • 1391Views
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SPLICELECT鈩�: an adaptable cell surface display technology based on alternative splicing allowing the qualitative and quantitative prediction of secreted product at a single-cell level
Christel Aebischer-Gumy, Pierre Moretti, Romain Ollier, Christelle Ries Fecourt, Fran莽ois Rousseau & Martin Bertschinger
旺财体育: 1709333
Published online: 19 Jan 2020
Abstract | Full Text | References | PDF (4469 KB) | Supplemental | Permissions聽

  • 1109Views
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Functional activity of anti-LINGO-1 antibody opicinumab requires target engagement at a secondary binding site
Karl J. M. Hanf, Joseph W. Arndt, YuTing Liu, Bang Jian Gong, Mia Rushe, Richelle Sopko, Ramiro Massol, Benjamin Smith, Yan Gao, Isin Dalkilic-Liddle, Xinhua Lee, Shanell Mojta, Zhaohui Shao, Sha Mi & R. Blake Pepinsky
旺财体育: 1713648
Published online: 17 Jan 2020
Abstract | Full Text | References | PDF (4805 KB) | Supplemental | Permissions聽

  • 1434Views
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Discovery and characterization of single-domain antibodies for polymeric Ig receptor-mediated mucosal delivery of biologics
Bharathikumar Vellalore Maruthachalam, Adam Zwolak, Xiefan Lin-Schmidt, Edward Keough, Ninkka Tamot, Sathya Venkataramani, Brian Geist, Sanjaya Singh & Rajkumar Ganesan
旺财体育: 1708030
Published online: 13 Jan 2020
Abstract | Full Text | References | PDF (3039 KB) | Supplemental | Permissions聽

  • 1583Views
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Molecular mechanism of an antagonistic antibody against glucose-dependent insulinotropic polypeptide receptor
Xiaoshan Min, Junming Yie, Jinghong Wang, Ben C. Chung, Ching-Shin Huang, Haoda Xu, Jie Yang, Liying Deng, Joanne Lin, Qing Chen, Christina M. Abbott, Caroline Gundel, Stephen A. Thibault, Tina Meng, Darren L. Bates, David J. Lloyd, Murielle M. V茅niant & Zhulun Wang
旺财体育: 1710047
Published online: 12 Jan 2020
Abstract | Full Text | References | PDF (5559 KB) | Supplemental | Permissions聽

  • 1445Views
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The impact of proline isomerization on antigen binding and the analytical profile of a trispecific anti-HIV antibody
Alessandro Masiero, Lechat Nelly, Gentric Marianne, Sourrouille Christophe, Laville Florian, Cr茅pin Ronan, Borel Claire, Ziegler Cornelia, Bisch Gr茅goire, Leclerc Eric, Laurent Ludovic, Brault Dominique, Alexandre Sylvie, Gagnaire Marie, Duffieux Francis, Soubrier Fabienne, Capdevila C茅cile, Arnould Isabelle, Dumas Jacques, Dabin J茅r么me, Genet Bruno, Rado拧evi膰 Katarina, Menet Jean-Michel & Prades Catherine
旺财体育: 1698128
Published online: 10 Jan 2020
Abstract | Full Text | References | PDF (3880 KB) | Supplemental | Permissions聽

  • 1986Views
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T cell epitope mapping of secukinumab and ixekizumab in healthy donors
Sebastian Spindeldreher, Anette Karle, Evelyne Correia, Maxime Tenon, Sascha Gottlieb, Thomas Huber, Bernard Maillere & Frank Kolbinger
旺财体育: 1707418
Published online: 10 Jan 2020
Abstract | Full Text | References | PDF (3540 KB) | Supplemental | Permissions聽

  • 1881Views
  • 1CrossRef citations
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VHH antibody targeting the chemokine receptor CX3CR1 inhibits progression of atherosclerosis
Sarah Low, Haixia Wu, Kavita Jerath, Annette Tibolla, Birgit Fogal, Rebecca Conrad, Margit MacDougall, Steven Kerr, Valentina Berger, Rajvee Dave, Jorge Villalona, Lynn Pantages, Jennifer Ahlberg, Hua Li, Diane Van Hoorick, Cedric Ververken, John Broadwater, Alisa Waterman, Sanjaya Singh & Rachel Kroe-Barrett
旺财体育: 1709322
Published online: 10 Jan 2020
Abstract | Full Text | References | PDF (2527 KB) | Supplemental | Permissions聽

  • 2054Views
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Homogeneous antibody-drug conjugates: DAR 2 anti-HER2 obtained by conjugation on isolated light chain followed by mAb assembly
Merc猫 Farr脿s, Joan Miret, Marc Camps, Ram贸n Rom谩n, 脫scar Mart铆nez, Xavier Pujol, St茅phane Erb, Anthony Ehkirch, Sarah Cianferani, Antoni Casablancas & Jordi Joan Cair贸
旺财体育: 1702262
Published online: 26 Dec 2019
Abstract | Full Text | References | PDF (4730 KB) | Permissions聽

  • 1716Views
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Rapid two-dimensional Protein-A size exclusion chromatography of monoclonal antibodies for titer and aggregation measurements from harvested cell culture fluid samples
Zachary D. Dunn, Jayesh Desai, Gabriel M. Leme, Dwight R. Stoll & Douglas D. Richardson
旺财体育: 1702263
Published online: 26 Dec 2019
Abstract | Full Text | References | PDF (1700 KB) | Supplemental | Permissions聽

  • 2126Views
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Perspective

article commentary
Antibodies to watch in 2020
H茅l猫ne Kaplon, Mrinalini Muralidharan, Zita Schneider & Janice M. Reichert
旺财体育: 1703531
Published online: 26 Dec 2019
Abstract | Full Text | References | PDF (2139 KB) | Permissions聽

  • 16761Views
  • 73CrossRef citations
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Report

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Design and characterization of mouse IgG1 and IgG2a bispecific antibodies for use in syngeneic models
Feng Wang, Jordan C. Tsai, Jonathan H. Davis, Bryant Chau, Jia Dong, Sean M. West, Jason M. Hogan, Matthew L. Wheeler, Christine Bee, Winse Morishige, Thomas Cayton, Donata David-brown, Chengyue Zhang, Alexander Kozhich, Tim Sproul, Gavin Dollinger, Arvind Rajpal & Pavel Strop
旺财体育: 1685350
Published online: 19 Dec 2019
Abstract | Full Text | References | PDF (1868 KB) | Supplemental | Permissions聽

  • 2494Views
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Monitoring glycation levels of a bispecific monoclonal antibody at subunit level by ultrahigh-resolution MALDI FT-ICR mass spectrometry
Christoph Gst枚ttner, Dietmar Reusch, Markus Haberger, Irina Dragan, Peter Van Veelen, David P. A. Kilgour, Yury O. Tsybin, Yuri E. M. van der Burgt, Manfred Wuhrer & Simone Nicolardi
旺财体育: 1682403
Published online: 18 Dec 2019
Abstract | Full Text | References | PDF (4447 KB) | Supplemental | Permissions聽

  • 2426Views
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Short Communication

rapid communication
Harnessing MerTK agonism for targeted therapeutics
Vivekananda Kedage, Diego Ellerman, Yongmei Chen, Wei-Ching Liang, Joven Borneo, Yan Wu & Minhong Yan
旺财体育: 1685832
Published online: 18 Dec 2019
Abstract | Full Text | References | PDF (2220 KB) | Supplemental | Permissions聽

  • 1142Views
  • 2CrossRef citations
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Report

report
Development of a quantitative relationship between CAR-affinity, antigen abundance, tumor cell depletion and CAR-T cell expansion using a multiscale systems PK-PD model
Aman P. Singh, Xirong Zheng, Xiefan Lin-Schmidt, Wenbo Chen, Thomas J. Carpenter, Alice Zong, Weirong Wang & Donald L. Heald
旺财体育: 1688616
Published online: 18 Dec 2019
Abstract | Full Text | References | PDF (6744 KB) | Supplemental | Permissions聽

  • 3325Views
  • 3CrossRef citations
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Clinical pharmacology of vc-MMAE antibody鈥揹rug conjugates in cancer patients: learning from eight first-in-human Phase 1 studies
Chunze Li, Cindy Zhang, Zao Li, Divya Samineni, Dan Lu, Bei Wang, Shang-Chiung Chen, Rong Zhang, Priya Agarwal, Bernard M. Fine & Sandhya Girish
旺财体育: 1699768
Published online: 18 Dec 2019
Abstract | Full Text | References | PDF (5433 KB) | Supplemental | Permissions聽

  • 1771Views
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Regulation of antibody-mediated complement-dependent cytotoxicity by modulating the intrinsic affinity and binding valency of IgG for target antigen
Bo Wang, Chunning Yang, Xiaofang Jin, Qun Du, Herren Wu, William Dall鈥橝cqua & Yariv Mazor
旺财体育: 1690959
Published online: 12 Dec 2019
Abstract | Full Text | References | PDF (6270 KB) | Supplemental | Permissions聽

  • 1998Views
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An engineered human IgG1 CH2 domain with decreased aggregation and nonspecific binding
Guangcan Cao, Xinyu Gao, Yancheng Zhan, Qingguang Wang, Zhe Zhang, Dimiter S. Dimitrov & Rui Gong
旺财体育: 1689027
Published online: 03 Dec 2019
Abstract | Full Text | References | PDF (4105 KB) | Supplemental | Permissions聽

  • 1562Views
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Structure-based engineering of pH-dependent antibody binding for selective targeting of solid-tumor microenvironment
Traian Sulea, Nazanin Rohani, Jason Baardsnes, Christopher R. Corbeil, Christophe Deprez, Yuneivy Cepero-Donates, Alma Robert, Joseph D. Schrag, Marie Parat, M茅lanie Duchesne, Maria L. Jaramillo, Enrico O. Purisima & John C. Zwaagstra
旺财体育: 1682866
Published online: 28 Nov 2019
Abstract | Full Text | References | PDF (5125 KB) | Supplemental | Permissions聽

  • 3645Views
  • 2CrossRef citations
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Dissecting the molecular basis of high viscosity of monospecific and bispecific IgG antibodies
Cholpon Tilegenova, Saeed Izadi, Jianping Yin, Christine S. Huang, Jiansheng Wu, Diego Ellerman, Sarah G. Hymowitz, Benjamin Walters, Cleo Salisbury & Paul J. Carter
旺财体育: 1692764
Published online: 28 Nov 2019
Abstract | Full Text | References | PDF (3506 KB) | Supplemental | Permissions聽

  • 2765Views
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Development of a high yielding expression platform for the introduction of non-natural amino acids in protein sequences
Gargi Roy, Jason Reier, Andrew Garcia, Tom Martin, Megan Rice, Jihong Wang, Meagan Prophet, Ronald Christie, William Dall鈥橝cqua, Sanjeev Ahuja, Michael A Bowen & Marcello Marelli
旺财体育: 1684749
Published online: 27 Nov 2019
Abstract | Full Text | References | PDF (5002 KB) | Supplemental | Permissions聽

  • 2261Views
  • 1CrossRef citations
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Defining the right diluent for intravenous infusion of therapeutic antibodies
Shen Luo, Keisha Melodi McSweeney, Tao Wang, Silvia M. Bacot, Gerald M. Feldman & Baolin Zhang
旺财体育: 1685814
Published online: 27 Nov 2019
Abstract | Full Text | References | PDF (14048 KB) | Supplemental | Permissions聽

  • 2620Views
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NHDL, a recombinant VL/VH hybrid antibody control for IgG2/4 antibodies
Corinna Lau, Martin Berner McAdamhttps://orcid.org/0000-0001-9385-6964, Grethe Bergseth, Algirdas Grevys, Jack Ansgar Bruun, Judith Krey Ludviksen, Hilde Fure, Terje Espevik, Anders Moen, Jan Terje Andersen & Tom Eirik Mollnes
旺财体育: 1686319
Published online: 27 Nov 2019
Abstract | Full Text | References | PDF (6610 KB) | Supplemental | Permissions聽

  • 1137Views
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Native size-exclusion chromatography-mass spectrometry: suitability for antibody鈥揹rug conjugate drug-to-antibody ratio quantitation across a range of chemotypes and drug-loading levels
Jay Jones, Laura Pack, Joshua H. Hunter & John F. Valliere-Douglass
旺财体育: 1682895
Published online: 26 Nov 2019
Abstract | Full Text | References | PDF (3022 KB) | Permissions聽

  • 2085Views
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Heparin chromatography as an in vitro predictor for antibody clearance rate through pinocytosis
Thomas E. Kraft, Wolfgang F. Richter, Thomas Emrich, Alexander Knaupp, Michaela Schuster, Andreas Wolfert & Hubert Kettenberger
旺财体育: 1683432
Published online: 26 Nov 2019
Abstract | Full Text | References | PDF (2157 KB) | Supplemental | Permissions聽

  • 1589Views
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In vivo safety profile of a CSPG4-directed IgE antibody in an immunocompetent rat model
Iwan P. Williams, Silvia Crescioli, Heng Sheng Sow, Heather J. Bax, Carl Hobbs, Kristina M. Ilieva, Elise French, Giulia Pellizzari, Vivienne Cox, Debra H. Josephs, James F. Spicer, Sophia N. Karagiannis & Silvia Mele
旺财体育: 1685349
Published online: 26 Nov 2019
Abstract | Full Text | References | PDF (9517 KB) | Supplemental | Permissions聽

  • 1119Views
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